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John Edward
Feb 17, 2023
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If you want to make a quality assignment then you must take help from Account Assignment Help, rather than wasting time on thinking about how to do this work on your own and you can easily find the genuine
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John Edward
Feb 17, 2023
|
If you want to make a quality assignment then you must take help from Account Assignment Help, rather than wasting time on thinking about how to do this work on your own and you can easily find the genuine
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John Edward
Jan 24, 2023
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If you want to make a quality assignment then you must take help from Essay Writing Help, rather than wasting time on thinking about how to do this work on your own and you can easily find the genuine
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litr la
Mar 11, 2021
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i Just Loved these novels the solo leveling light novel and beginning after the end
https://lightnovelshub.com/novel/solo-levelling-novel/
https://lightnovelshub.com/novel/the-beginning-after-the-end/
https://lightnovelshub.com/novel/solo-levelling-novel/
https://lightnovelshub.com/novel/the-beginning-after-the-end/
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Women Health1
Jan 05, 2023
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WHAT ARE THE RISKS OF FAMILY HISTORY OF PROSTATE CANCER ICD 10?
If you wonder, are there any risks if someone has a family history of prostate cancer icd 10?, then prostate cancer seems to run in some families only, which tells that only in some cases there may be an inherited or genetic factor. Otherwise, prostate cancers occur in men without having any family history of it.
Having a brother or a father with prostate cancer actually doubles the risks for a man to develop this disease. Even the risk is higher for those who have a brother with this disease than for those who have a father with it and so the risk is much higher for those who have several affected relatives.
Read more: https://www.womenhealth1.com/history-of-prostate-cancer-icd-10/
If you wonder, are there any risks if someone has a family history of prostate cancer icd 10?, then prostate cancer seems to run in some families only, which tells that only in some cases there may be an inherited or genetic factor. Otherwise, prostate cancers occur in men without having any family history of it.
Having a brother or a father with prostate cancer actually doubles the risks for a man to develop this disease. Even the risk is higher for those who have a brother with this disease than for those who have a father with it and so the risk is much higher for those who have several affected relatives.
Read more: https://www.womenhealth1.com/history-of-prostate-cancer-icd-10/
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Elise Elleneth
Jan 16, 2019
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Later, am going to update the novel ESCORT... I have to edit first and polish my English. ☺
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Ridham
May 02, 2025
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Targeted drug delivery system Market Growth and Status Explored in a New Research Report 2035
The prevalence of chronic diseases has increased significantly over the past few decades. Presently, around 129 million people in the US have at least one life threating chronic condition, such as heart disease, cancer, diabetes, obesity or hypertension.
The global targeted drug delivery device market size is projected to grow from $427 Million in 2026 to $2,153 Million by 2035, representing a CAGR of 19.7% during the forecast period.
Additionally, about 90% of the annual USD 4.1 trillion health care expenditure is attributed to managing and treating chronic diseases and mental health conditions. Thus, rising incidence of chronic diseases, coupled with aging population has led to a surge in the demand for novel drugs, including complex small molecules and biologics, across multiple therapeutic areas.
The pharmaceutical industry is increasingly shifting towards biologics over traditional small molecule drugs due to their higher specificity and efficacy in treating complex diseases, particularly through targeted drug delivery devices. Biologics are designed to interact with specific cellular targets, which can lead to more effective treatments with fewer side effects. In 2023, the US FDA approved around 20 biologics for various indications, highlighting their growing acceptance. However, the administration of biologics often requires injections rather than oral routes, posing challenges for patient compliance. Further, over the years, biologics have demonstrated a high success rate (more than 70%) in various clinical trials across different therapeutic areas. As the industry continues to innovate, enhancing drug delivery systems will be crucial for maximizing the benefits of biologics.
Advantages of targeted drug delivery device
Targeted Drug Delivery Devices offer a number of benefits. Some of the key advantages offered by these devices are summarized below:
Minimally Invasive: Current systems for delivering cell therapies are often inefficient and require invasive procedures for direct injection into targeted tissues. For patients with conditions like heart failure, multiple invasive surgeries are required to achieve optimal therapeutic effects due to the need for several injections. In contrast, targeted drug delivery devices offer a solution by enabling localized therapies to be administered minimally invasively as many times as required. These devices are implanted into the target tissue through a single surgical procedure, after which the cells within the device's reservoir can produce therapeutic effects and facilitate the healing of damaged tissue. Additionally, catheter-based injection systems have been shown to effectively provide safe and minimally invasive targeted delivery of cell therapies.
Limited Systemic Toxic Side-effects: Majority of the biologics, including cell therapies, gene therapies and immunotherapies are being delivered systemically rather than being delivered directly to the targeted site. The systemic administration of these therapies can cause toxicity by activating the immune response, resulting in adverse side effects such as fatigue, nausea, easy bruising, and infection. Additionally, patients often need to visit clinics every week or two for frequent repeated administrations of these therapies. The targeted drug delivery devices deliver the therapeutics to the targeted site easily, maximizing target site exposure, generate elicit efficient therapeutic response, and reduces the risk of immunogenicity.
Sustained Delivery: The high tumoral pressure makes it challenging for a drug to be effective when administered directly to the tumor in a single dose. This is primarily due to the fact that only a small amount of drug gets reaches the targeted site while the remaining gets eliminated. The intra-tumoral implantable drug delivery devices represent a significant advancement in the field of cancer therapy by enabling sustained drug release. These systems are designed to release therapeutic agents at a controlled rate, significantly improving treatment efficacy and safety.
Encapsulated Cell Therapy Implants: Targeted drug delivery via encapsulated cell therapy implants enables the safe and efficient administration of cell therapies. Encapsulation of therapeutic cells and their implantation into the surgical cavity allows for long term release of active compounds at the required site, reducing side effects associated with systemic delivery. Most encapsulation strategies also function as biomimetic scaffolds, providing the necessary structural support for cell survival and proliferation.
Research objectives:
• The Targeted Drug Delivery Device Market report studies the worldwide market consumption rate in terms of value and volume.
• It identifies the various sub-segments of the market structure.
• It proffers information regarding the leading global manufacturers in this industry, describing their market value & share, sales volume, competitive analysis, SWOT analysis, and development strategies adopted during the forecast timeline.
• The report describes the key industry players, with respect to their individual growth trends, future prospects, and contribution to the global market, and explains the factors related to their market growth potential, drivers, opportunities, threats, and industry-specific challenges.
• Furthermore, the report underpins the strategic developments occurring in the global market, such as expansions, mergers & acquisitions, agreements, as well as new product launches.
Thank you for reading our report. Kindly get in touch with us to know more about the report or to receive a customized copy of it. Our team will ensure the report is tailored according to your needs.
The prevalence of chronic diseases has increased significantly over the past few decades. Presently, around 129 million people in the US have at least one life threating chronic condition, such as heart disease, cancer, diabetes, obesity or hypertension.
The global targeted drug delivery device market size is projected to grow from $427 Million in 2026 to $2,153 Million by 2035, representing a CAGR of 19.7% during the forecast period.
Additionally, about 90% of the annual USD 4.1 trillion health care expenditure is attributed to managing and treating chronic diseases and mental health conditions. Thus, rising incidence of chronic diseases, coupled with aging population has led to a surge in the demand for novel drugs, including complex small molecules and biologics, across multiple therapeutic areas.
The pharmaceutical industry is increasingly shifting towards biologics over traditional small molecule drugs due to their higher specificity and efficacy in treating complex diseases, particularly through targeted drug delivery devices. Biologics are designed to interact with specific cellular targets, which can lead to more effective treatments with fewer side effects. In 2023, the US FDA approved around 20 biologics for various indications, highlighting their growing acceptance. However, the administration of biologics often requires injections rather than oral routes, posing challenges for patient compliance. Further, over the years, biologics have demonstrated a high success rate (more than 70%) in various clinical trials across different therapeutic areas. As the industry continues to innovate, enhancing drug delivery systems will be crucial for maximizing the benefits of biologics.
Advantages of targeted drug delivery device
Targeted Drug Delivery Devices offer a number of benefits. Some of the key advantages offered by these devices are summarized below:
Minimally Invasive: Current systems for delivering cell therapies are often inefficient and require invasive procedures for direct injection into targeted tissues. For patients with conditions like heart failure, multiple invasive surgeries are required to achieve optimal therapeutic effects due to the need for several injections. In contrast, targeted drug delivery devices offer a solution by enabling localized therapies to be administered minimally invasively as many times as required. These devices are implanted into the target tissue through a single surgical procedure, after which the cells within the device's reservoir can produce therapeutic effects and facilitate the healing of damaged tissue. Additionally, catheter-based injection systems have been shown to effectively provide safe and minimally invasive targeted delivery of cell therapies.
Limited Systemic Toxic Side-effects: Majority of the biologics, including cell therapies, gene therapies and immunotherapies are being delivered systemically rather than being delivered directly to the targeted site. The systemic administration of these therapies can cause toxicity by activating the immune response, resulting in adverse side effects such as fatigue, nausea, easy bruising, and infection. Additionally, patients often need to visit clinics every week or two for frequent repeated administrations of these therapies. The targeted drug delivery devices deliver the therapeutics to the targeted site easily, maximizing target site exposure, generate elicit efficient therapeutic response, and reduces the risk of immunogenicity.
Sustained Delivery: The high tumoral pressure makes it challenging for a drug to be effective when administered directly to the tumor in a single dose. This is primarily due to the fact that only a small amount of drug gets reaches the targeted site while the remaining gets eliminated. The intra-tumoral implantable drug delivery devices represent a significant advancement in the field of cancer therapy by enabling sustained drug release. These systems are designed to release therapeutic agents at a controlled rate, significantly improving treatment efficacy and safety.
Encapsulated Cell Therapy Implants: Targeted drug delivery via encapsulated cell therapy implants enables the safe and efficient administration of cell therapies. Encapsulation of therapeutic cells and their implantation into the surgical cavity allows for long term release of active compounds at the required site, reducing side effects associated with systemic delivery. Most encapsulation strategies also function as biomimetic scaffolds, providing the necessary structural support for cell survival and proliferation.
Research objectives:
• The Targeted Drug Delivery Device Market report studies the worldwide market consumption rate in terms of value and volume.
• It identifies the various sub-segments of the market structure.
• It proffers information regarding the leading global manufacturers in this industry, describing their market value & share, sales volume, competitive analysis, SWOT analysis, and development strategies adopted during the forecast timeline.
• The report describes the key industry players, with respect to their individual growth trends, future prospects, and contribution to the global market, and explains the factors related to their market growth potential, drivers, opportunities, threats, and industry-specific challenges.
• Furthermore, the report underpins the strategic developments occurring in the global market, such as expansions, mergers & acquisitions, agreements, as well as new product launches.
Thank you for reading our report. Kindly get in touch with us to know more about the report or to receive a customized copy of it. Our team will ensure the report is tailored according to your needs.
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brunoboys
Feb 11, 2023
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Experience the Thrill of NFL Daily Fantasy at Bruno Boys
NFL Daily Fantasy is a fantasy football game where players draft a new team for each game rather than for an entire season. NFL Daily Fantasy at Bruno Boys offers a quick and exciting way for fans to enjoy their favorite sport and a chance to win real money. Visit our website for better assistance!
https://brunoboys.net/category/dfs/nfl/
NFL Daily Fantasy is a fantasy football game where players draft a new team for each game rather than for an entire season. NFL Daily Fantasy at Bruno Boys offers a quick and exciting way for fans to enjoy their favorite sport and a chance to win real money. Visit our website for better assistance!
https://brunoboys.net/category/dfs/nfl/
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Marriott Michael
Sep 23, 2025
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The shop was a forgotten comma in the long, run-on sentence of the city. Tucked between a bustling coffee shop and a laundromat that hummed day and night, "Aethelstan's Curiosities" seemed to absorb sound rather than generate it. The window was a mosaic of dust motes dancing in the slanted afternoon light, showcasing a collection of objects with no obvious connection: a single, tarnished silver spoon, a birdcage with a missing door, a porcelain doll with one eye closed in a perpetual wink.
Inside, Elara moved with the slow, deliberate grace of a cat. At seventy-two, she was the latest in a long line of Keepers, though the line had thinned to just her. The air smelled of old paper, lemon polish, and time itself. Her life was a ritual of small, precise actions: dusting the shelves, polishing the brass, and listening.
Inside, Elara moved with the slow, deliberate grace of a cat. At seventy-two, she was the latest in a long line of Keepers, though the line had thinned to just her. The air smelled of old paper, lemon polish, and time itself. Her life was a ritual of small, precise actions: dusting the shelves, polishing the brass, and listening.
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AmilStyle
Oct 20, 2018
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He subido el nuevo capitulo de Game of the Gods
https://www.wattpad.com/story/162884335-game-of-the-gods-journey-to-a-fantasy-world-anture/parts
https://tumangaonline.me/library/novel/41031/game-of-the-gods-journey-to-a-fantasy-world-anture
https://www.wattpad.com/story/162884335-game-of-the-gods-journey-to-a-fantasy-world-anture/parts
https://tumangaonline.me/library/novel/41031/game-of-the-gods-journey-to-a-fantasy-world-anture
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Marriott Michael
Sep 23, 2025
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The shop was a forgotten comma in the long, run-on sentence of the city. Tucked between a bustling coffee shop and a laundromat that hummed day and night, "Aethelstan's Curiosities" seemed to absorb sound rather than generate it. The window was a mosaic of dust motes dancing in the slanted afternoon light, showcasing a collection of objects with no obvious connection: a single, tarnished silver spoon, a birdcage with a missing door, a porcelain doll with one eye closed in a perpetual wink.
Inside, Elara moved with the slow, deliberate grace of a cat. At seventy-two, she was the latest in a long line of Keepers, though the line had thinned to just her. The air smelled of old paper, lemon polish, and time itself. Her life was a ritual of small, precise actions: dusting the shelves, polishing the brass, and listening.
Inside, Elara moved with the slow, deliberate grace of a cat. At seventy-two, she was the latest in a long line of Keepers, though the line had thinned to just her. The air smelled of old paper, lemon polish, and time itself. Her life was a ritual of small, precise actions: dusting the shelves, polishing the brass, and listening.
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Alan Luiz
Aug 15, 2022
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Ukraine War: The Donbas body collector who has lost count
Aleksey Yukov standing next to the white van, marked with a red cross
Image caption,
Aleksey Yukov and his men recover dead bodies of Ukrainian and Russian soldiers killed in combat in the Donbas
Aleksey Yukov has lost count of the bodies he's recovered in the Donbas over the past five months. He says he thinks it's more than 300, but he can't be sure.
Aleksey and his men drive a refrigerated white van, marked with a red cross, to carry out their work. They often drive towards danger to collect the bodies and remains of dead Ukrainian and Russian troops and civilians.
"We work with no days off. Constantly. We drive, we investigate, we transport, we search, all the time," he says.
It's grim work too - digging up the decomposing bodies of Russian soldiers buried in shallow trenches, or gathering their remains from burnt out armoured vehicles.
According to the United Nations, more than 5,000 Ukrainian civilians have been killed since Russia invaded in February.
There are no official figures for how many Ukrainian troops have died. But one adviser to President Zelensky told the BBC last month that between 100-200 Ukrainian soldiers were being killed every day. On average it's at the lower end of that scale.
Aleksey says that figure sounds realistic to him. But he believes the Russians are losing three times that number.
One Ukrainian soldier we spoke to, who had fought in Severodonetsk, described Russian tactics as similar to the First World War - with waves of their infantry running into a hail of bullets.
Smoke rising near homes in Donbas
Image caption,
Smoke rises near homes in the eastern Donbas region, where Russia has targeted its ground offensive
Who does Aleksey think is winning the war? "It's not about who is winning," he says. "It's about who's right. They [Russia] came here and that was unforgivable".
Every Ukrainian soldier we spoke to said they still believed they could win. Even in units that had suffered combat casualties of more than half of the troops.
But it's taking its toll on the living as well as the dead. Aleksey hasn't seen his one-year-old daughter for months.
"This war has ruined the life you had and the one you've been building," he says.
He adds that at the end of the day it all catches up: "That feeling when you are empty inside. The unfillable void".
Why Russia wants to seize Ukraine's eastern Donbas
Death comes quickly in the Donbas. Russian shells take mere seconds to land, and they're being used in industrial quantities. On average Russia is firing 20,000 artillery shells a day. Ukraine is able to respond with just 6,000.
There's no respite from the sound of heavy shelling at a military medical station we visit. The chief medical officer - who only wants to be known as Dr Anatoliy for his own safety - describes the situation on the frontline as "fragile".
He shows us photographs of a badly damaged military ambulance - riddled with bullet holes and torn to shreds by shrapnel. Dr Anatoliy says the red cross painted on their vehicles mean nothing to Russians. Two more ambulances are waiting outside the building under camouflage nets - ready to go to pick up the injured.
Tina packing a military bag inside an ambulance
Image caption,
Before volunteering to join the army Tina worked at a children's hospital
We meet Tina and Polina, two front line medics.
Tina used to work at a children's hospital before she volunteered to join the army. She wipes away tears as she talks about the family she's now missing.
"The pain goes away, because you have a task: to get a person to a hospital alive" she says. I ask if she's scared. "Of course it's scary. When a shell lands nearby, everything shrinks inside you".
For every soldier killed many more are injured. Tina says she's not allowed to give numbers but adds "there are casualties almost every day, and not just one. Sometimes many, sometimes a lot".
Polina standing near a vehicle
Image caption,
Twenty-one-year-old Polina says she exercises and listens to music to keep some sense of normality
Polina is just 21. The war's already cast a big shadow over her short life.
Her father and uncle are now prisoners in Russian-occupied Ukraine. She says she's trying her best not to let it get her down. She exercises and listens to music whenever she can - just to keep some sense of normality.
But Polina admits it's hard not to feel gloomy and depressed: "Apart from the bullets flying over your head, wounded people - and those wounded are often my friends and buddies - if you're taking it to heart it's going to be tough".
It's the troops she treats who give her hope.
"The guys who are injured and exhausted don't even want to go to hospital sometimes. They say I'm not going to leave my mates, we're holding the line together".
line
War in Ukraine: More coverage
RUSSIA: Stop the fighting: Russian soldier's mum speaks out
WATCH: War nears Ukraine maternity ward
ANALYSIS: Is the tank doomed?
READ MORE: Full coverage of the crisis
Aleksey Yukov standing next to the white van, marked with a red cross
Image caption,
Aleksey Yukov and his men recover dead bodies of Ukrainian and Russian soldiers killed in combat in the Donbas
Aleksey Yukov has lost count of the bodies he's recovered in the Donbas over the past five months. He says he thinks it's more than 300, but he can't be sure.
Aleksey and his men drive a refrigerated white van, marked with a red cross, to carry out their work. They often drive towards danger to collect the bodies and remains of dead Ukrainian and Russian troops and civilians.
"We work with no days off. Constantly. We drive, we investigate, we transport, we search, all the time," he says.
It's grim work too - digging up the decomposing bodies of Russian soldiers buried in shallow trenches, or gathering their remains from burnt out armoured vehicles.
According to the United Nations, more than 5,000 Ukrainian civilians have been killed since Russia invaded in February.
There are no official figures for how many Ukrainian troops have died. But one adviser to President Zelensky told the BBC last month that between 100-200 Ukrainian soldiers were being killed every day. On average it's at the lower end of that scale.
Aleksey says that figure sounds realistic to him. But he believes the Russians are losing three times that number.
One Ukrainian soldier we spoke to, who had fought in Severodonetsk, described Russian tactics as similar to the First World War - with waves of their infantry running into a hail of bullets.
Smoke rising near homes in Donbas
Image caption,
Smoke rises near homes in the eastern Donbas region, where Russia has targeted its ground offensive
Who does Aleksey think is winning the war? "It's not about who is winning," he says. "It's about who's right. They [Russia] came here and that was unforgivable".
Every Ukrainian soldier we spoke to said they still believed they could win. Even in units that had suffered combat casualties of more than half of the troops.
But it's taking its toll on the living as well as the dead. Aleksey hasn't seen his one-year-old daughter for months.
"This war has ruined the life you had and the one you've been building," he says.
He adds that at the end of the day it all catches up: "That feeling when you are empty inside. The unfillable void".
Why Russia wants to seize Ukraine's eastern Donbas
Death comes quickly in the Donbas. Russian shells take mere seconds to land, and they're being used in industrial quantities. On average Russia is firing 20,000 artillery shells a day. Ukraine is able to respond with just 6,000.
There's no respite from the sound of heavy shelling at a military medical station we visit. The chief medical officer - who only wants to be known as Dr Anatoliy for his own safety - describes the situation on the frontline as "fragile".
He shows us photographs of a badly damaged military ambulance - riddled with bullet holes and torn to shreds by shrapnel. Dr Anatoliy says the red cross painted on their vehicles mean nothing to Russians. Two more ambulances are waiting outside the building under camouflage nets - ready to go to pick up the injured.
Tina packing a military bag inside an ambulance
Image caption,
Before volunteering to join the army Tina worked at a children's hospital
We meet Tina and Polina, two front line medics.
Tina used to work at a children's hospital before she volunteered to join the army. She wipes away tears as she talks about the family she's now missing.
"The pain goes away, because you have a task: to get a person to a hospital alive" she says. I ask if she's scared. "Of course it's scary. When a shell lands nearby, everything shrinks inside you".
For every soldier killed many more are injured. Tina says she's not allowed to give numbers but adds "there are casualties almost every day, and not just one. Sometimes many, sometimes a lot".
Polina standing near a vehicle
Image caption,
Twenty-one-year-old Polina says she exercises and listens to music to keep some sense of normality
Polina is just 21. The war's already cast a big shadow over her short life.
Her father and uncle are now prisoners in Russian-occupied Ukraine. She says she's trying her best not to let it get her down. She exercises and listens to music whenever she can - just to keep some sense of normality.
But Polina admits it's hard not to feel gloomy and depressed: "Apart from the bullets flying over your head, wounded people - and those wounded are often my friends and buddies - if you're taking it to heart it's going to be tough".
It's the troops she treats who give her hope.
"The guys who are injured and exhausted don't even want to go to hospital sometimes. They say I'm not going to leave my mates, we're holding the line together".
line
War in Ukraine: More coverage
RUSSIA: Stop the fighting: Russian soldier's mum speaks out
WATCH: War nears Ukraine maternity ward
ANALYSIS: Is the tank doomed?
READ MORE: Full coverage of the crisis
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Elise Elleneth
Jan 06, 2019
|
Hello folks! First, I apologize for not uploading Rise of the King oneshot novel yet. But to make up, I upload The King's Mistress instead! Hope you'll like it! Thanks! 👇👇👇 link below:
https://www.niadd.com/chapter/THE_KING_S_MISTRESS/100030385/
https://www.niadd.com/chapter/THE_KING_S_MISTRESS/100030385/
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Retro Senpai
Jul 20, 2019
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if you guess ever have any questions about re zero don't be fraud to ask me I will answer it to the best of my abilities and knowledge of the anime and web novel I have watch and read
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