Active Gaming Media and Tezuka Productions announced on September 14 that their Astro Boy: Edge of Time digital card game received a new expansion that adds Vampires and Witches based on Tezuka's The Vampires manga to the game. The companies also added new skills to the game, as well as 100 new cards and a new faction.

Active Gaming Media launched a Kickstarter campaign for the game in August 2016, but canceled it three days before the campaign ended, with only US$7,255 of its US$50,000 goal. However, the game's parallel crowdfunding campaign on the Japanese Makuake site was successful. DMM released the game as a free-to-play digital card game with in-app purchases for PC on April 12. The game also had planned iOS and Android versions, but these are not currently listed on the game's website. The game received a PC release via Steam on June 19.

The game is based on the works of manga pioneer Osamu Tezuka. His son Macoto Tezka is supervising the project. The game's cards feature Tezuka's characters redesigned by modern artists, including Hiroya Oku (Gantz, Inuyashiki manga creator).